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Dr. Sauerbrey has directed the Onchocerciasis Elimination Program for the Americas since 1998 and has worked extensively on public health control programs, particularly malaria control, leading the successful Malaria Control Program in El Salvador, with United States Agency for International Development assistance. In the area of parasitic disease, he has directed the Centers of Disease Control and Prevention's Central America Research Station, and served as advisor for USAID in Central America.

He has been a full-time professor in communicable diseases at the School of Medicine in El Salvador, a vector-borne diseases specialist/consultant at the International Center for Public Health Research and Training of the University of South Carolina, and adjunct professor in the Public Health Department of Environmental Health Sciences at the College of Health of the University of South Carolina. In addition, Dr. Sauerbrey has been a member of the Expert Advisory Panel on Malaria and the Steering Committee on Epidemiology and Vector Biology and Control of Chagas Disease at the World Health Organization and the Special Program for Research and Training in Tropical Disease, WHO/TDR.