Seroreversion to Chlamydia Trachomatis Pgp3 Antigen among Children in a Hyperendemic Region of Amhara, Ethiopia

Description: Trachoma programs are considering the use of serology to monitor transmission and recrudescence as populations approach elimination. In hyperendemic settings, serological measures of transmission serve as a baseline against which progress can be measured. In this longitudinal cohort, 2-3% of seropositive children experienced seroreversion of IgG responses to chlamydia antigen Pgp3 each year, demonstrating that seroreversion is unlikely to influence estimates of seroconversion rates among young children in hyperendemic settings.

Subcategory: Tools